Effects of Different Forms of Progesterone on the threat of Spontaneous Pregnancy

Abstract

This article discusses the effects of different forms of progesterone on the risk of miscarriage. Pregnancy involves a complex interplay between maternal neuro end ocrine and immunological systems in order to establish and sustain a growing fetus. Here we review research to date that focus on the pathways through which P4 mediates its actions on both the maternal reproductive and immune system. We will dissect the role of P4 as a modulator of inflammation, both systemic and intrinsic to the uterus, during human pregnancy and labor. The effects of different forms of progesterone on the risk of spontaneous abortion have also been analyzed.