Comparative Analysis of ITGB 3 Gene Polymorphism in Fetal Growth Retardation Syndrome

Abstract

The article presents a molecular genetic study of the ITGB3 gene polymorphism in pregnant women with fetal growth restriction syndrome.

Purpose. Assessment of the detectability of the association of the ITGB3 gene polymorphism in women with physiological pregnancy and fetal growth restriction syndrome in the uzbek population of the Bukhara region.

Materials and methods 80 pregnant women were examined during gestation from 8-36 weeks: 40 pregnant women with fetal growth restriction syndrome and 40 women with physiological pregnancy, hospitalized in the department of pathology of pregnant women in the Bukhara city maternity hospital in the city of Bukhara.

Conclusion. The study showed that the functionally unfavorable allele C and the association of the T / C genotype polymorphism of the ITGB3 gene polymorphism can be a determinant of an increased risk of developing FGRS in Uzbekistan (χ2 <0.47; P> 0.05).