Peculiarities of the Action of Fosmetrine on Bioenergetic Processes in Mitochondria and Lipid Metabolism in RAT Liver

Authors

  • Askar Usmanovich Sadikov Head of Laboratory, Research Institute for Sanitation, Hygiene and Occupational Diseases
  • Khamrakulova Mukaddaskhon Askarovna Head of the course on professional diseases of the Centre The course in occupational diseases of the Centre for Development of Professional Skills of Medical Workers Centre for Development of Professional Skills of Medical Workers
  • Nasiba Fayzullaeva Ubaidullaeva Researcher at the Laboratory of Biomedical Research in Hygiene of the Scientific-Research Institute of Sanitary, Hygiene and Occupational Diseases, Ministry of Health Sanitary, Hygiene and Occupational Diseases Research Institute of the Ministry of Health of the Republic of Uzbekistan
  • Sadikov Usman Askarovich Lecturer of the Fiscal Institute under the State Tax Committee Tax Committee of the Republic of Uzbekistan

Keywords:

Phosphomethrin, pesticides, mitochondria, liver, total lipids, phospholipids

Abstract

Administration of 440 g/l (0.2 ml per 100 g body weight intraperitoneally) to male rats leads to a significant decrease in respiration rate of liver mitochondria in the 3rd metabolic state and to some activation in the 2nd metabolic state after 2 h of poisoning with their further partial normalization by 20 h. A decrease in the efficiency of oxidative phosphorylation of ADP in mitochondria correlates with the dynamics of phospholipid and β-lipoprotein content in the liver. Disturbances of bioenergetic processes in mitochondria precede the accumulation of total lipids in the liver. The decrease of cholesterol content in liver tissue is the result of disruption of its synthesis in the membranes of endoplasmic reticulum.

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Published

2021-11-16

How to Cite

Sadikov, A. U. ., Askarovna, K. M. ., Ubaidullaeva, N. F. ., & Askarovich, S. U. . (2021). Peculiarities of the Action of Fosmetrine on Bioenergetic Processes in Mitochondria and Lipid Metabolism in RAT Liver. International Journal of Discoveries and Innovations in Applied Sciences, 1(6), 53–56. Retrieved from https://oajournals.net/index.php/ijdias/article/view/623

Issue

Vol. 1 No. 6 (2021): November

Section

Articles